Increased DNA damage and DNA damage response (DDR) activation is well-documented in cardiovascular disease (CVD) and heart failure in humans, but no current treatment strategies exist to target this population. By applying cutting-edge optical, biological, and bioelectrical tools, McGowan Institute for Regenerative Medicine affiliated faculty member Tzahi Cohen-Karni, PhD, Associate Professor in the Department of Biomedical Engineering at Carnegie Mellon University, and his team will map cardiac tissue cell-cell communication and electrophysiology in response to stochastic endogenous DNA damage. Deeper understanding of the regulatory network that mediates the genotoxic stress response in the cardiac tissue will suggest preventive strategies and therapeutic interventions to reduce public health burden.
This project, entitled “Mapping the cell specific DNA damage-induced molecular and bioelectrical responses in the 3D cardiac unit,” will run for 5 years. It is funded by the National Heart, Lung, and Blood Institute.